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The research suggests that Canova medication act in the modulation of the immune response through:
- Macrophages activation; which modifies its structure and enhances its function.
- Absence of toxicity and mutagenicity.
- Relative increase of total number of subtypes of leukocytes and lymphocytes (CD4, CD8, NK and B), reverting – partly the effect of some pathologies.
- Increase production of nitric oxide by macrophages.
- Decrease production of TNF-a, reversing the frames of cachexia.
- Increase phagocytosis index and the endosomal-lysosomal system index in macrophages, increasing these cells efficiency in organic defense.
- Decrease of the inflammatory response, accelerating healing process.
- Decrease tumor volume and production of fibrosis (collagen type I) around the tumor mass.
- Restoration of several hematological parameters turning it applicable during and after chemotherapy, improving the tolerability and duration of treatments against cancer.
- Reduction and containment of Leishmania amazonensis by macrophages.
- Decrease of opportunistic diseases.
International Journals Indexed
Dissertations and Thesis presented at Pos-graduation Strictu Senso Programs
Works Published in National and International Congress with Approval of Referees (Scientific Referees)
The research contained in the restricted area may assist understanding the drug´s activity on the cells of the body´s defense, as well, use in academic papers, lectures and presentations provided with the source.
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